Pathway Control in Cooperative vs. Anti‐Cooperative Supramolecular Polymers

Supramolecular polymers: Chain growth in control.

Supramolecular polymers are a class of materials characterized by a repetition of monomer units held together by non-covalent forces such as metal coordination, π–π interactions and hydrogen bonding1–4. Compared with their covalent counterparts the unique properties of these polymers have attracted considerable attention, for instance, the self-healing ability that arises from the thermodynamic...

Cooperative and anticooperative binding to a ribozyme.

The effects of guanosine 5'-monophosphate and 2'-deoxyguanosine 5'-monophosphate on the thermodynamics and kinetics of pyrene-labeled 5' exon mimic (pyCUCU) binding to the catalytic RNA (ribozyme) from Tetrahymena thermophila have been determined by fluorescence titration and kinetics experiments at 15 degrees C. pyCUCU binding to L-21 Sca I-truncated ribozyme is weaker by a factor of 5 in the ...

Spatiotemporal control and superselectivity in supramolecular polymers using multivalency.

Multivalency has an important but poorly understood role in molecular self-organization. We present the noncovalent synthesis of a multicomponent supramolecular polymer in which chemically distinct monomers spontaneously coassemble into a dynamic, functional structure. We show that a multivalent recruiter is able to bind selectively to one subset of monomers (receptors) and trigger their cluste...

Metallo-supramolecular cyclic polymers.

Cyclic brush polymers represent an exciting new macromolecular topology. For the first time, this new topology has been combined with metallo-supramolecular interactions to construct novel cyclic brush polymers. Here, ring-expansion metathesis polymerization was used to synthesize a universal cyclic template with a polynorbornene backbone, which was further modified with the metal-chelating syn...

Multiple Hydrogen-Bonded Supramolecular Polymers